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Medchemexpress LLC SKLB325 | 66680-03-3 | 99.2% | 244.25 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY139782100MG

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SKLB325 is a Jumonji domain-containing 6 (JMJD6) inhibitor with a binding affinity (KD) value of 0.755 μM and an IC50 value of 0.7797 μM. It exhibits antitumor effects on ovarian cancer in vivo and in vitro, and induces apoptosis. It also shows remarkable antitumor efficacy in renal cell carcinoma (RCC).

  • Inhibits proliferation and induces apoptosis and cell death in ovarian cancer cells.
  • Plays a significant role in inhibiting tumor growth by inhibiting angiogenesis.
  • Upregulates the expression of p53 and its downstream effectors at both mRNA and protein levels.
  • Demonstrates antitumor activities in an intraperitoneal xenograft model.
  • Prolongs the survival of tumor-bearing mice without obvious side effects.
  • Effective in suppressing tumor growth in nude mice.

Catalog No. 50-003-50387


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