AdipoGen Slc7a8 Lat2 pAb

Supplier:  AdipoGen AG25T0120C100

Polyclonal Antibody. Recognizes mouse and human Slc7a8. Other species not tested.Detects a ~50kDa Slc7a8 band in wild type mouse brain, kidney, jejunum, ileum and other tissues, which is absent in knock-out animals. In some tissues the antibody detects an additional unknown 38kDa band. Source Rabbit. Applications IHC, WB. Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. L-type amino acid transporter LAT family members are Na-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 SLC7A5, LAT2 SLC7A8, LAT3 SLC43A1 and LAT4 SLC43A2 are responsible for the majority of cellular leucine uptake. They show increased expression in many cancers and are critical for control of protein translation and cell growth through the mTORC1 pathway. The increased transporter expression observed in cancers is regulated by transcriptional pathways such as hormone receptors, c-myc and nutrient starvation responses.

Catalog No. 50-256-3154