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Medchemexpress LLC SLMP53-2 | 1826116-38-4 | C26H22N2O2 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1532025MG

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SLMP53-2 is a mutant p53 reactivator that restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with Hsp70, leading to the reestablishment of p53 transcriptional activity. It can induce cell cycle arrest, apoptosis, and endoplasmic reticulum (ER) stress, and exhibits antitumor activity.

  • Restores wild-type-like function to mutant p53.
  • Enhances interaction with Hsp70 to reestablish p53 transcriptional activity.
  • Induces cell cycle arrest, apoptosis, and endoplasmic reticulum (ER) stress.
  • Exhibits antitumor activity.
  • Inhibits growth of various cancer cell lines.
  • Reduces tumor volume and weight in xenograft mouse models.

Catalog No. 50-004-05242


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