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ACROBiosystems Human SMAC Protein, His Tag, >95% Purity, 1 mg

Catalog No. 501658874
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Human SMAC, also known as DIABLO, is a mitochondrial protein that acts as an activator of caspase by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). This protein promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway and inhibits BIRC6/bruce activity by preventing its binding to caspases. This recombinant protein is expressed in E. coli cells and contains amino acids Ala 56 - Asp 239 with a C-terminal polyhistidine tag.

  • Greater than 95% purity as determined by SDS-PAGE.
  • Calculated molecular weight of 21.7 kDa.
  • Lyophilized from a 0.22 μm filtered solution in 20 mM HEPES, 150 mM NaCl, pH 7.5 with trehalose.
  • Stable for 12 months in lyophilized state at -20°C to -70°C.
  • Validated for technical research applications.

Catalog No. 50-165-8874 Supplier ACROBiosystems Supplier No. DIOH51291MG
May include imposed supplier surcharges.
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Human SMAC, also known as DIABLO, is a mitochondrial protein that acts as an activator of caspase by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). This protein promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway and inhibits BIRC6/bruce activity by preventing its binding to caspases. This recombinant protein is expressed in E. coli cells and contains amino acids Ala 56 - Asp 239 with a C-terminal polyhistidine tag.

  • Greater than 95% purity as determined by SDS-PAGE.
  • Calculated molecular weight of 21.7 kDa.
  • Lyophilized from a 0.22 μm filtered solution in 20 mM HEPES, 150 mM NaCl, pH 7.5 with trehalose.
  • Stable for 12 months in lyophilized state at -20°C to -70°C.
  • Validated for technical research applications.

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