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AdipoGen SMAD4h mAb recPAS7-C7
Supplier: AdipoGen AG27B6331C050
Recombinant Antibody. Recognizes human SMAD4. Applications ELISA, ICC, PLA. Clone PAS7-C7. Isotype Human IgG1. Formulation Liquid. In PBS. The TGF-beta signaling pathway regulates key cell fate decisions during embryonic development and in adult homeostasis. This pathway is deregulated in many pathological conditions, including cancer, autoimmunity and fibrotic diseases. TGF-beta functions as a tumor suppressor in early tumors, inhibiting progression through the cell cycle. TGF-beta binds a heterotetrameric cell surface complex composed of type I and II serine/threonine kinase TGF-beta receptors TGFBRI and TGFBRII. Ligand binding causes receptor phosphorylation and transmission of the signal to a class of intracellular intermediates, the receptor-regulated SMAD proteins.
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