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Enzo Life Sciences SMER28 (5mg). CAS: 307538-42-7
Supplier: Enzo Life Sciences BMLEI3970005
Chemical inducer of autophagy which acts via an mTOR-independent mechanism. It increased autophagosome synthesis and enhanced the clearance of model autophagy substrates such as A53T α-synuclein and mutant huntingtin fragments. It reduced Aβ peptide and AAP-CTF levels in an Alzheimers model and attenuated mutant huntingtin-fragment toxicity in Huntington’s disease models, suggesting therapeutic potential. Alternative name: 6-Bromo-4-allylaminoquinazoline. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (8mg/ml) or 100% ethanol (2mg/ml). Long Term Storage: -20°C.
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