STEMCELL Technologies SMER28, Size: 10 mg

Supplier:  STEMCELL Technologies 74204

Enhance mammalian autophagy with SMER28. This bromo-substituted quinazoline induces autophagy by increasing autophagosome synthesis and enhancing the clearance of model autophagy substrates (Renna et al. J Biol Chem, 2010). SMER28 has various applications in disease modeling, such as stimulating erythropoiesis and upregulating expression of globin genes in both in vitro and in vivo models of Diamond-Blackfan anemia (Doulatov et al. Sci Transl Med, 2017); enhancing clearance of autophagy substrates including mutant huntingtin in Huntington's disease and A53T α-synuclein in familial Parkinson's disease (Sarkar et al. Nat Chem Biol, 2007); and decreasing the level of indicators of Alzheimer's disease via the autophagy-related protein 5-dependent pathway (Tian et al. FASEB J, 2011). SMER28 is supplied as a crystalline solid with ≥ 98% purity; Molecular weight 264.1 g/mol; CAS number 307538-42-7. Visit STEMCELL.com for more information and related products.

Catalog No. 50-197-6199