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Medchemexpress LLC SMIFH2 | 340316-62-3 | 99.1% | 377.21 | 50 MG
Supplier: Medchemexpress LLC HY1693150MG
SMIFH2 is a formin specific inhibitor that inhibits actin polymerization by Formins and affects the actin cytoskeleton. It induces dynamic cytoskeletal remodelling in U2OS cells at 25 uM. SMIFH2 also reduces p300, mDia2 and p53 levels in a proteasome-independent manner and reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton.
- Formin specific inhibitor
- Inhibits actin polymerization by Formins
- Affects the actin cytoskeleton
- Induces dynamic cytoskeletal remodelling in U2OS cells
- Reduces p300, mDia2 and p53 levels in a proteasome-independent manner
- Reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism
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