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Medchemexpress LLC SN-011 | 2249435-90-1 | 99.9% | C25H19FN2O4S | 100 MG
Supplier: Medchemexpress LLC HY145010100MG
SN-011 is a potent and selective mouse and human STING inhibitor with an IC50 of 76 nM for STING signaling. It competes with cyclic dinucleotide (CDN) for the STING dimer binding pocket, blocking CDN binding and activation. This product is used for research into STING-driven autoimmune and inflammatory diseases.
- Suppresses STING stimulator-induced expression of Ifnb, Cxcl10, and Il6 mRNA in mouse embryonic fibroblasts.
- Inhibits 2′3′-cGAMP-induced Ifnb expression and STING oligomerization/phosphorylation.
- Suppresses STING ER-to-Golgi translocation.
- Inhibits inflammation and autoimmunity in vivo.
- Protects Trex1-/- mice from death, improves survival, and reduces multiorgan inflammation.
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