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Medchemexpress LLC SN-38 glucuronide | 121080-63-5 | 99.5% | 568.53 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY126373

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SN-38 glucuronide (SN-38G) is an inactive metabolite of Irinotecan, an anticancer active molecule, and has toxic effects on the gastrointestinal tract. Irinotecan functions as a topoisomerase I inhibitor and is utilized in research related to colon and rectal cancer.

  • Cells capable of metabolizing SN-38 to SN-38G show increased resistance to extracellular SN-38.
  • Can serve as a substrate for gut microbial β-glucuronidase enzymes.
  • These enzymes remove the glucuronic acid moiety, which reactivates SN-38.
  • Reactivation of SN-38 in the intestine can intensify its toxic effects on the gut.

Catalog No. 50-004-39147


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