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Medchemexpress LLC SN-38 glucuronide (SN-38G) | 121080-63-5 | 99.5% | 568.53 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY12637310MG

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SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.

  • Inactive metabolite of the anticancer active molecule irinotecan.
  • Has toxic effects on the gastrointestinal tract.
  • Cells capable of metabolizing SN38 to SN38-G show increased resistance to extracellular SN38.
  • Can serve as a substrate for gut microbial β-glucuronidase enzymes, which reactivate SN-38 in the intestine, leading to increased toxic effects on the gut.

Catalog No. 50-004-38072


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