List Biological Laboratories Inc SNAPtide Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin, 200 nmoles

Supplier:  List Biological Laboratories Inc 521

SNAPtide Peptide Substrate (FITC/DABCYL) is a synthetic peptide that containes the native cleavage site for botulinum neurotoxin type A. The peptide is a quenched fluorescent substrate peptide based on FRET. Cleavage of the substrate by the appropriate botulinum neurotoxin releases the fluorophore and full fluorescence is restored. The increase in fluorescence intensity is directly proportional to the amount of cleavage that has occurred and thus allows for accurate measurement of the botulinum neurotoxin enzymatic activity. The FRET substrates can be used for development of highly sensitive and rapid in vitro methods with the potential for 1) detesting toxin contamination in food, clinical, and environmental samples; 2) evaluating potency of botulinum neurotoxin therapeutic agents; 3) detecting toxin neutralizing antibodies; as well as 4) screening and characterizing a large number of toxin inhibitors, which are potential therapeutic agents.

Catalog No. 50-101-8837