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Apexbio Technology LLC Sodium butyrate(Synonyms: Butyric acid sodium salt, Sodium n-butyrate, Sodium butanoate, Sodium salt of butyric acid), 10mM (in 1mL H2O), CAS: 156-54-7.
Supplier: Apexbio Technology LLC B18355.1
Sodium butyrate (CAS 156-54-7) is a small-molecule inhibitor of histone deacetylases (HDACs) enzymes that regulate gene expression by deacetylating histone proteins By inhibiting HDAC activity sodium butyrate increases histone acetylation levels modifying transcription factor functions and subsequently affecting gene transcription In vitro sodium butyrate promotes apoptosis in colorectal adenoma and carcinoma cell lines (RG/C2 and AA/CI respectively) suggesting anticancer research applications In vivo sodium butyrate administration in transgenic mouse models of Huntington s disease improved survival motor function and mitigated neuropathological damage Thus sodium butyrate is valuable in biomedical research targeting epigenetic regulation and neurodegenerative diseases
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