Sodium deoxycholate monohydrate, 97%, Thermo Scientific Chemicals

Description

Sodium deoxycholate is a bile acid salt that contains a deoxycholate group and shows choleretic activity. It is used as a biological detergent to lyse cells and to solubilize cellular and membrane components.

Sodium deoxycholate is used as a choleretic and an anionic detergent. It is useful for the extraction of membrane receptors, plasma membrane proteins, nuclei isolation and solubilizes fats as well as membrane components. It acts as an intermediate for the production of corticosteroids and microbiological diagnostic media. In addition, it acts as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Sodium deoxycholate is a bile salt and an ionic detergent
• It is a bile acid formed by bacterial action from cholate
• Sodium deoxycholate is considered to be a cholagogue and choleretic since it promotes the flow of bile into the duodenum (cholagogues) or stimulates bile production by the liver (choleretic)

Application

• In chemical approaches, sodium deoxycholate acts as an intermediate for corticosteroid production
• This compound is used to lyse cells and to extract cellular and membrane components, including membrane receptors, plasma membrane proteins, and nuclei, and allows the solubilization of fats for intestinal absorption and membrane components
• Sodium deoxycholate is also used to prepare microbiological diagnostic media and acts as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins
• In biological experiments, sodium deoxycholate has been used in the lysis buffer prepared for brown adipose tissue
• It is also used in the decellularization of aortic valvular conduit

Specifications

Chemical Identifiers

• CAS: 145224-92-6
• Molecular Formula: C24H41NaO5
• Molecular Weight (g/mol): 432.58
• MDL Number: MFCD00150750 MFCD00064139
• InChI Key: NDVHNZISGVSFMP-WTCAICSISA-M
• Synonym: 7-Deoxycholic acid sodium salt
• PubChem CID: 91810855
• IUPAC Name: sodium (4R)-4-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11S,11aR)-7,11-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoate hydrate
• SMILES: O.[Na+].[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)[C@H](C)CCC([O-])=O

• Color: White
• Physical Form: Powder
• Quantity: 25 g
• Beilstein: 3581950
• Solubility Information: Soluble in waterSoluble in water,dimethyl sulfoxide and methanol; Slightly soluble in ethanol.
• Formula Weight: 414.6
• Percent Purity: 97%
• Chemical Name or Material: Sodium deoxycholate

Safety and Handling

missing translation for 'healthHazard1'	H302-H335
missing translation for 'healthHazard2'	GHS H Statement H302-H315-H319-H335 Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
missing translation for 'healthHazard3'	P261-P264b-P270-P271-P301+P312-P304+P340-P312-P330-P501c
EINECSNumber	206-132-7
RTECSNumber	FZ2250000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only