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AdipoGen Sodium dichloroacetate
Supplier: AdipoGen AGCR13684G001
Chemical. CAS 2156-56-1. Formula C2HCl2O2 . Na. MW 127.9 . 23.0. Synthetic. Analog of acetic acid. Mitochondrial pyruvate dehydrogenase kinase PDK inhibitor, consequently activating pyruvate dehydrogenase PDH. Decreases glycolysis. Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Antitumor agent. Decreases tumor growth in vitro and in vivo. Induces mitochondrial-dependent apoptosis. Useful agent for immunometabolism research. Glucose entering the cell is metabolized by glycolysis to pyruvate. Most of the pyruvate in non-cancerous cells enters the mitochondria under aerobic conditions and a small fraction is metabolized to lactate. PDH in mitochondria converts pyruvate into acetyl-CoA, which enters the TCA cycle. In cancer cells, the oxidative mitochondrial pathway of glucose utilization is suppressed and most of the pyruvate is converted into lactate Warburg effect.
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