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Apexbio Technology LLC Sodium Phenylbutyrate 1716-12-7 200mg
Supplier: Apexbio Technology LLC A4107200
Sodium Phenylbutyrate (CAS 1716-12-7) is a small-molecule inhibitor targeting histone deacetylase (HDAC) an enzyme involved in regulating histone acetylation an epigenetic mechanism implicated in cancer progression and cardiac dysfunction In oral squamous cell carcinoma cell lines (CAL27 HSC3 SCC4) Sodium Phenylbutyrate demonstrated dose-dependent cell growth inhibition (IC50 4 091 3 712 and 3 015 mM respectively) and decreased cell viability in a time-dependent manner In a mouse Adriamycin-induced cardiac injury model treatment with Sodium Phenylbutyrate significantly attenuated cardiac enzyme elevations improved cardiac function and increased cardiac MnSOD protein expression and activity Sodium Phenylbutyrate serves as an important research tool for cancer biology and cardiotoxicity studies
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