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Apexbio Technology LLC Sodium Tauroursodeoxycholate (TUDC) 35807-85-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B60195.1
Sodium tauroursodeoxycholate (TUDC CAS 35807-85-3) is a taurine-conjugated bile salt studied for its modulating effects on cholestasis In human erythrocytes TUDC inhibits bile salt-induced efflux of the fluorochrome BCPCF via MRP1 exhibiting an IC50 of 560 M In vitro TUDC partially reverses 17 -estradiol glucuronide (17 EG)-induced reduction of cholyllysylfluorescein canalicular accumulation suggesting an influence on bile secretion dynamics In rat models of phalloidin-induced cholestasis TUDC administration decreases biochemical markers of liver injury and improves biliary excretion of cholesterol and phospholipids These properties make TUDC relevant for research on hepatoprotection and cholestatic mechanisms
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