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Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | 99.9% | 681.49 | 50 MG
Supplier: Medchemexpress LLC HY1658250MG
Sonidegib diphosphate is a potent and selective Smoothened (Smo) antagonist that reduces the expression of downstream Hedgehog (Hh) signaling targets. It demonstrates dose-related antitumor activity in various preclinical models and is currently undergoing clinical trials for conditions such as Basal Cell Carcinoma and Hepatocellular Carcinoma.
- Potent and selective Smoothened (Smo) antagonist
- Reduces expression of downstream Hedgehog (Hh) signaling targets
- Inhibits Hh pathway in CD34+ chronic phase (CP)-chronic myeloid leukaemia (CML) cells
- Demonstrates dose-related antitumor activity in medulloblastoma models
- Undergoing clinical trials for various conditions
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