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ABclonal Technology Sorbitol Dehydrogenase
Supplier: ABclonal Technology A21952100UL
Sorbitol dehydrogenase (SORD EC 1 1 1 14) catalyzes the interconversion of polyols and their corresponding ketoses and together with aldose reductase (ALDR1 MIM 103880) makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham 1995 [PubMed 8535074]) The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor SORD then oxidizes the sorbitol to fructose using NAD( ) cofactor
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