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AdipoGen Sortilin human rec His
Supplier: AdipoGen AG40B0229C050
Recombinant Protein. Human sortilin aa 78-755 is fused at the C-terminus to a His-tag. Source W2. Lyophilized. Contains PBS. Sortilin is a type I transmembrane multiligand receptor that is a member of the Vacuolar protein sorting 10 protein Vps10p domain receptor family. It is a 95 kDa protein, ubiquitously expressed, although most abundantly expressed in neurons, hepatocytes, adipocytes and white blood cells including macrophages. Sortilin is synthesized as a propeptide in the endoplasmic reticulum ER and processed to its mature form by furin-mediated cleavage in the trans-Golgi network. The primary function of sortilin is trafficking proteins from the Golgi to secretory vesicles and endolysosomal compartments. The majority of trafficking is from the Golgi to the endosomal compartment where sortilin deposits cargo targeted for catabolism in the lysosome and then is trafficked back to the Golgi via a retromer complex.
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