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Apexbio Technology LLC Sotalol hydrochloride 959-24-0 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC B33415.1

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Sotalol hydrochloride (CAS 959-24-0) is a potent non-selective -adrenergic receptor antagonist and a potassium channel inhibitor In HEK cell models it exhibits an IC50 of approximately 1 2 mM for potassium channel inhibition As a class III antiarrhythmic agent sotalol hydrochloride increases the functional refractory period without reducing conduction velocity in ex vivo rabbit heart models of reentrant tachycardia In vivo studies in canine hearts demonstrate its ability to prolong atrial and ventricular monophasic action potential durations during constant atrial pacing Sotalol hydrochloride is frequently employed in research on arrhythmia mechanisms and rhythm control therapies particularly in the context of atrial fibrillation

Catalog No. 50-000-94687


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