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Medchemexpress LLC Soticlestat | 1429505-03-2 | 99.8% | 373.45 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY10912310MG

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Soticlestat is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor with potential for epilepsy syndromes research.

  • Inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) with an IC50 of 4.5 nM.
  • Lowers brain 24S-hydroxycholesterol in a dose-dependent manner.
  • Significantly reduces premature deaths in APP/PS1-Tg mice.
  • Suppresses potassium-evoked extracellular glutamate elevations in the hippocampus.

Catalog No. 50-003-45042


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