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Medchemexpress LLC Sotuletinib hydrochloride | 2222138-31-8 | 99.43% | 25 MG
Supplier: Medchemexpress LLC 25MGHY12768A
Sotuletinib hydrochloride is a potent, selective, orally active, and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM. It demonstrates more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs. This compound is valuable for research involving microglia depletion, and studies related to tumor and CNS-related diseases.
- Potent, selective, orally active, and brain-penetrant CSF-1R (c-Fms) inhibitor
- IC50 of 1 nM
- High selectivity, more than 1,000-fold against closest receptor tyrosine kinase homologs
- Useful for microglia depletion studies
- Applicable in tumor and CNS-related disease research
- Inhibits CSF-1-dependent proliferation in bone marrow-derived macrophages
- Decreases CSF-1R phosphorylation
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