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Medchemexpress LLC Sovesudil hydrochloride | 2984963-50-8 | 99.5% | 443.90 | 25 MG

Supplier: Medchemexpress LLC 25MGHY109191A
Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. It lowers intraocular pressure (IOP) without inducing hyperemia.
- Potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor
- IC50s of 3.7 nM for ROCK-I and 2.3 nM for ROCK-II
- Lowers intraocular pressure (IOP) without inducing hyperemia
- Induces altered cellular behavior of human trabecular meshwork (HTM) cells in vitro
- Effectively reduces IOP in ocular normotensive and acute hypertensive rabbits without causing distinct hyperemia in vivo
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