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Apexbio Technology LLC SP 600125 129-56-6 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A46045.1

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SP 600125 (CAS 129-56-6) is a selective reversible ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK) with reported IC50 values of 40 nM for JNK1 and JNK2 and 90 nM for JNK3 Initially identified via GST-c-Jun substrate and recombinant human JNK2 screening assays SP 600125 demonstrates marked specificity being approximately 300-fold more selective toward JNK isoforms compared to ERK1 and p38-2 kinases In cellular assays SP 600125 effectively suppresses JNK-mediated phosphorylation of c-Jun and attenuates expression of IL-2 IFN- and TNF- It is widely utilized in inflammation and signal transduction research

Catalog No. 50-000-61426


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