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Cayman Chemical Sp-8-bromo-CyclIc AMPsodIu 5mg
Supplier: Cayman Chemical 160025 MG
An orally bioavailable pyridone derivative with antifibrotic anti-inflammatory and antioxidant activities inhibits TGF-B1-stimulated increases in collagen type I fibronectin and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner inhibits fibrosis and inhibits increases in collagen content fibrocyte pool size and the levels of chemokines CCL2 and CCL12 at 300 mg/kg in lung in a mouse model of pulmonary fibrosis induced by bleomycin inhibits fibrosis and increases in hepatocyte apoptosis lobular inflammation and hepatic expression of the fibrosis-related genes Col1a1 Timp1 Tgfb1 Pdgfb and Fgf2 in a mouse model of NASH at 280 mg/kg inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s ~6 and ~2.5 mM respectively)
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