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Enzo Life Sciences SP600125, (10mg), CAS Number: 129-56-6
SDP

Supplier:  Enzo Life Sciences BMLEI3050010

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Jnk inhibitor. Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes. Alternative Name: Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone. Formula: C14H8N2O. MW: 220.2. CAS Number: 129-56-6. Purity: ≥98% (TLC). Appearance: Yellow to brown solid. Solubility: Soluble in DMSO or methanol. Use/Stability: Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C. Long Term Storage: Ambient

Catalog No. NC9772181


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