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Enzo Life Sciences SP600125 (50mg). CAS: 129-56-6
Supplier: Enzo Life Sciences BMLEI3050050
Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes. Alternative name: Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone. Purity: ≥98% (TLC). Solubility: Soluble in DMSO or methanol. Long Term Storage: Ambient.
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