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Selleck Chemical LLC SP600125 50mg 129-56-6 Nsc75890
Supplier: Selleck Chemical LLC S146050MG
SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKC?, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad?spectrum inhibitor of serine/threonine kinases including Aurora kinase A,FLT3 and TRKA with of IC50 of 60?nM, 90?nM and 70?nM. SP600125 inhibits autophagy and activates apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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