STEMCELL Technologies SP600125, Size: 5 mg

Supplier:  STEMCELL Technologies 72642

SP600125 is a potent and reversible inhibitor of JNK1-3 (IC₅₀ = 0.11 μM) (Bennett et al.). It is cell-permeable and dose-dependently inhibits c-JUN phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN- in T-cells (Bennett et al.).REPROGRAMMING· Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, RepSox, Forskolin, Gö6983, Valproic Acid and Y-27632 (Hu et al.).DIFFERENTIATION· Inhibits BMP9-induced osteogenic differentiation in cultured mouse mesenchymal stem cells (MSCs) and in primary bone marrow stromal cells (Zhao et al.).· Promotes adipogenic, but represses osteogenic differentiation of human MSCs (Bilkovski et al.; Liu et al.; Qiu et al.; Tominaga et al.).· Causes cell death and inhibits neurogenesis when added during early stages of neuronal culture (Tiwari et al.).

Catalog No. 50-197-5955