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Medchemexpress LLC Spadin TFA | 99.7% | 2126.36 | 5 MG
SDP

Catalog No. 5000424806
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Spadin TFA is a natural peptide derived from a propeptide found in blood. It is a potent TREK-1 channel blocker with an IC50 value of 10 nM. This peptide enhances dorsal raphe nucleus 5-HT neurotransmission in mice and promotes hippocampal CREB activation and neurogenesis. It is used in antidepressant research.

  • Potent TREK-1 channel blocker (IC50 value of 10 nM)
  • Enhances dorsal raphe nucleus 5-HT neurotransmission in mice
  • Induces hippocampal CREB activation and neurogenesis
  • Inhibits TREK-1 channel and blocks 63% of TREK-1 current stimulated by arachidonic acid in COS-7 cells (100 nM)
  • Blocks TREK-1 channel activity in CA3 hippocampal neurons on brain slices of wild-type mice (100 nM)
  • Increases 5-HT neuron firing rate in the dorsal raphe nucleus (DRN) in male C57Bl/6J and TREK-1 deficient mice
  • Shows anti-depressant behavior in mice

Catalog No. 50-004-24806 Supplier Medchemexpress LLC Supplier No. HYP1422A5MG
May include imposed supplier surcharges.
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Spadin TFA is a natural peptide derived from a propeptide found in blood. It is a potent TREK-1 channel blocker with an IC50 value of 10 nM. This peptide enhances dorsal raphe nucleus 5-HT neurotransmission in mice and promotes hippocampal CREB activation and neurogenesis. It is used in antidepressant research.

  • Potent TREK-1 channel blocker (IC50 value of 10 nM)
  • Enhances dorsal raphe nucleus 5-HT neurotransmission in mice
  • Induces hippocampal CREB activation and neurogenesis
  • Inhibits TREK-1 channel and blocks 63% of TREK-1 current stimulated by arachidonic acid in COS-7 cells (100 nM)
  • Blocks TREK-1 channel activity in CA3 hippocampal neurons on brain slices of wild-type mice (100 nM)
  • Increases 5-HT neuron firing rate in the dorsal raphe nucleus (DRN) in male C57Bl/6J and TREK-1 deficient mice
  • Shows anti-depressant behavior in mice

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