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Medchemexpress LLC Sparfosic acid trisodium | 70962-66-2 | 98.0% | 321.06 | 100 MG
Supplier: Medchemexpress LLC HY112732B100MG
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase, an enzyme that catalyzes the second step of de novo pyrimidine biosynthesis. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. This product is for research use only and not intended for sale to patients.
- Potent inhibitor of aspartate transcarbamoyl transferase.
- Synergistically enhances cytotoxicity of 5-FU and IFN against human colon cancer cell lines.
- Causes apoptosis in resistant Br1 cells.
- Leads to progressive accumulation of cells in S phase and activation of an apoptotic pathway.
- Increases lifespan and is curative in mice models of B16 melanoma and Lewis lung carcinoma.
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