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Echelon Biosciences Research LabsSupplier Diversity Partner SPHINGOSINE KINASE INHIBITOR (SK1-II) 5 mg  DFS Item

Manufacturer:  Echelon Biosciences Research LabsSupplier Diversity Partner B002450MG

2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) is a cell permeable, potent, and specific inhibitor of sphingosine kinase (IC50 = 0.5 μM). The compound does not bind to the ATP-binding site and does not affect the kinase activities of hERK2, hPI3K, or hPKCα at concentrations up to 60 μM. SK1-II showed anti-tumor properties, inducing apoptosis in a number of cell lines including those that express Pgp or MRP1 drug-transport proteins.\n\n


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Solubility

\nDMSO, >5 mg/mL\n\n
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Documents
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\n\nTechnical Data Sheet

Catalog No. 50-720-005


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