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Cayman Chemical SphngomyelInporcIn RBC 100mg
SDP

Supplier:  Cayman Chemical 31558100 MG

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An inhibitor of PARP1 and 2 (EC50s 10 2 and 36 3 M respectively in yeast cells expressing the human enzymes) decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells at 50 M reduces NF-KB-induced transcription of the genes encoding TNF-a IL-2 and IFN-Y in rat lymphocytes reduces spinal cord expression of iNOS IL-1B TNF-a IL-2 and IFN-Y and reduces disease score in a rat model of EAE at 60 mg/kg decreases serum levels of lactate dehydrogenase as well as hepatic lipid peroxidation oxidative DNA damage and PARP levels in a mouse model of carbon tetrachloride-induced hepatotoxicity at 10 mg/kg

Catalog No. 50-299-0981


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