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Cayman Chemical SphngomyelInporcIn RBC 50mg

Supplier: Cayman Chemical 3155850 MG

A positive modulator of Kv3 1b Kv3 2a and Kv3 3 (EC50s 4 7 4 9 and 31 6 UM respectively in a patch-clamp assay) selective for Kv3 1b Kv3 2a and Kv3 3 over Kv1 5 and Kv7 1/minK channels but also inhibits the 5-HT transporter 5-HT3 receptor and a1 subunit-containing nAChR in a panel of 26 ion channels receptors and transporters increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices at 1 and 10 UM
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