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Cayman Chemical SphngosIn KInase 2 InhIbIto 96
Supplier: Cayman Chemical 70187096 WELL
A DAPK1 (IC50 200 nM) and DAPK3 inhibitor selectively binds to DAPK1 DAPK2 and DAPK3 (Kds 300 79 and 280 nM respectively) over Pim-1 Pim-2 and Pim-3 (Kds 1800 6500 and 810 nM respectively) but does inhibit Pim-3 (IC50 200 nM) inhibits phosphorylation of RLC20 in primary human coronary artery smooth muscle cells at 10 UM reduces phenylephrine-induced contractions in isolated mouse aortic rings and increases the time to reach 50 maximal contractions in calyculin A-stimulated isolated rat caudal arterial smooth muscle strips at 10 and 100 UM respectively
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