Medchemexpress LLC Spi-112 | 1051387-90-6 | MFCD31620831 | 98.0% | 468.46 g/mol | C22H17FN4O5S | 1 ML

Supplier:  Medchemexpress LLC HY10196410MM 1ML

SPI-112 is a potent, selective, and competitive inhibitor of SHP2 (PTPN11) used for in vitro biochemical and biophysical studies. It inhibits SHP2 with an IC50 of approximately 1 μM, with weaker activity against related phosphatases. Kinetic and binding data indicate competitive inhibition (Ki ≈ 0.8 μM) and 1:1 binding by SPR (KD ≈ 1.3 μM). The compound is not cell permeable and is supplied for research applications.

• Inhibits SHP2 with IC50 ≈ 1 μM.
• Shows selectivity over related phosphatases (IC50s 18.3 μM for PTP, 14.5 μM for PTP1B).
• Exhibits competitive inhibition kinetics (Ki ≈ 0.8 μM).
• Binds 1:1 in SPR with KD ≈ 1.3 μM.
• Not cell permeable due to polar or charged functional groups.
• Supplied as a solid and as a 10 mM solution for in vitro assays.
• High purity suitable for biochemical assays (≈98%).
• Store solid at 4°C; in solvent store at -80°C (long term) or -20°C (short term).

Catalog No. 50-002-48009