Medchemexpress LLC Spirosolan-3-ol, hydrochloride (1:1), (3β,5α,22β,25S)- | 6192-62-7 | 25 MG

Supplier:  Medchemexpress LLC 25MGHYN2149A

Tomatidine hydrochloride is an anti-inflammatory agent that blocks NF-κB and JNK signaling. It also activates autophagy in mammalian cells and C. elegans. This product is for research use only and has not been fully validated for medical applications.

• Decreases inducible NO synthase and COX-2 expression
• Suppresses I-κBα phosphorylation, NF-κB nuclear translocation, and JNK activation
• Inhibits c-jun phosphorylation and Oct-2 expression
• Causes dose-dependent inhibition of LPS-induced iNOS expression
• Suppresses NF-κB binding activity at 10-40 μM
• Blocks I-κB production and suppresses p65 NF-κB translocation to the nucleus
• Attenuates osteoclastogenesis by inhibiting MAPK, NF-κB, and PI3K/Akt signaling pathways in vitro

Catalog No. 50-004-22024