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Medchemexpress LLC Spirosolan-3-ol, hydrochloride (1:1), (3β,5α,22β,25S)- | 6192-62-7 | 25 MG
SDP

Catalog No. 5000422024
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Tomatidine hydrochloride is an anti-inflammatory agent that blocks NF-κB and JNK signaling. It also activates autophagy in mammalian cells and C. elegans. This product is for research use only and has not been fully validated for medical applications.

  • Decreases inducible NO synthase and COX-2 expression
  • Suppresses I-κBα phosphorylation, NF-κB nuclear translocation, and JNK activation
  • Inhibits c-jun phosphorylation and Oct-2 expression
  • Causes dose-dependent inhibition of LPS-induced iNOS expression
  • Suppresses NF-κB binding activity at 10-40 μM
  • Blocks I-κB production and suppresses p65 NF-κB translocation to the nucleus
  • Attenuates osteoclastogenesis by inhibiting MAPK, NF-κB, and PI3K/Akt signaling pathways in vitro

Catalog No. 50-004-22024 Supplier Medchemexpress LLC Supplier No. 25MGHYN2149A
May include imposed supplier surcharges.
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Tomatidine hydrochloride is an anti-inflammatory agent that blocks NF-κB and JNK signaling. It also activates autophagy in mammalian cells and C. elegans. This product is for research use only and has not been fully validated for medical applications.

  • Decreases inducible NO synthase and COX-2 expression
  • Suppresses I-κBα phosphorylation, NF-κB nuclear translocation, and JNK activation
  • Inhibits c-jun phosphorylation and Oct-2 expression
  • Causes dose-dependent inhibition of LPS-induced iNOS expression
  • Suppresses NF-κB binding activity at 10-40 μM
  • Blocks I-κB production and suppresses p65 NF-κB translocation to the nucleus
  • Attenuates osteoclastogenesis by inhibiting MAPK, NF-κB, and PI3K/Akt signaling pathways in vitro

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