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Medchemexpress LLC Spliceostatin A | 391611-36-2 | 94.7% | 521.64 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY164661MG

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Spliceostatin A is a potent anti-tumor agent derived from FR901464 (HY-16212) through methylation. It functions by inhibiting splicing and causing pre-mRNA accumulation, achieved by binding to SF3B1, a component of the U2 small nuclear ribonucleoprotein in the spliceosome. This action leads to the induction of apoptosis in chronic lymphocytic leukemia (CLL) cells.

  • Potent anti-tumor agent.
  • Inhibits splicing and promotes pre-mRNA accumulation by binding to SF3B1.
  • Induces apoptosis in chronic lymphocytic leukemia (CLL) cells.
  • Available in various quantities.
  • Ships with dry ice and stores at -80°C, protected from light.
  • Soluble in DMSO (50 mg/mL).

Catalog No. 50-003-91424


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