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Medchemexpress LLC SPP-86 | 1357349-91-7 | 99.9% | 277.32 | 100 MG
Supplier: Medchemexpress LLC HY11019310MM/1ML
SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. It inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, and also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells. This compound is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM.
- Inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling.
- Inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells.
- Click chemistry reagent, containing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
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