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Medchemexpress LLC SPR741 acetate | 99.4% | 1052.18 | 100 MG
Supplier: Medchemexpress LLC HYP1649B100MG
SPR741 acetate is a cationic peptide derived from polymyxin B, functioning as a potentiator molecule. It enhances the permeability of the outer membrane of Gram-negative bacteria, making it useful for treating severe Gram-negative bacterial infections and inhibiting multidrug-resistant Gram-negative bacteria. While it lacks significant antibacterial activity on its own, it increases the accumulation of co-administered antibiotics inside the pathogen and has an improved safety profile compared to polymyxin B.
- Enhances permeability of Gram-negative bacterial outer membrane
- Useful for treating severe Gram-negative bacterial infections
- Inhibits multidrug-resistant Gram-negative bacteria
- Broadens activity spectrum of antibiotics when combined
- Potentiates antibiotics that are substrates of the AcrAB-TolC efflux pump
- Improved safety profile compared to polymyxin B
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