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Cayman Chemical SPramIpexolehydroCLOrId 100mg
Supplier: Cayman Chemical 11981100 MG
A dopamine D2S, D2L, D3, and D4 receptor agonist (EC50s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [35S]GTPγS binding assay); a partial agonist of α2A-ARs (EC50 = 3,548.13 nM); selective for dopamine D2-4 receptors (Kis = 954.99, 1,698.24, 12.59, 128.82 nM for for D2S, D2L, D3, and D4 receptors, respectively, in a radioligand binding assay) over D1 and D5 receptors (Kis = >10,000 nM for both); prevents MPTP-induced decreases in the number of dopaminergic neurons in the substantia nigra pars compacta in common marmosets at 60 μg/kg per day before, during, and after administration of MPTP
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