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Medchemexpress LLC SR-4835 | 2387704-62-1 | 99.5% | 50 MG
Supplier: Medchemexpress LLC HY13025050MG
SR-4835 is a potent, highly selective, and ATP-competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). It acts synergistically with DNA-damaging chemotherapy and PARP inhibitors, leading to cell death in triple-negative breast cancer (TNBC) cells.
- Potent, highly selective, and ATP-competitive dual inhibitor of CDK12/CDK13
- Inhibits CDK12 (IC50=99 nM, Kd=98 nM)
- Inhibits CDK13 (Kd=4.9 nM)
- Acts synergistically with DNA-damaging chemotherapy and PARP inhibitors
- Leads to cell death in triple-negative breast cancer (TNBC) cells
- Suppresses ATM and RAD51 protein levels
- Triggers intronic polyadenylation site cleavage
- Suppresses expression of core DNA damage response proteins
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