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Cayman Chemical SR 59230AhydrochlorIde 25mg

Supplier: Cayman Chemical 2140725 MG

An iron chelator with antiproliferative effects inhibits in vitro proliferation of SK-N-MC neuroepithelioma SK-Mel-28 melanoma and MCF-7 breast cancer cells (IC50s 30 60 and 60 nM respectively) increases mobilization of 59Fe from SK-N-MC cells and M109 mouse lung carcinoma cells (25 and 1 UM respectively) enhances cytotoxicity in several multidrug resistant human cancer cell lines following transport to lysosomes by P-glycoprotein inhibits M109 tumor growth in mice reducing tumor weight to 47 of control values (0 4 mg/kg) reduces tumor size and weight in an oral squamous cell carcinoma mouse xenograft model (0 5 mg/kg)
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