TARGETMOL CHEMICALS INC SR9009 25MG

Supplier:  TARGETMOL CHEMICALS INC T368525MG

Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SR9009 (Stenabolic) a REV-ERB agonist increases the constitutive repression of genes regulated by REV-ERB(alpha)/ERB(beta) (IC50 670/800 nM). Through activation of REV-ERB SR9009 can decrease circadian locomotor activity during the dark phase and alter the expression pattern of core clock genes in the hypothalami of mice. The circadian pattern of expression of an array of metabolic genes in the liver skeletal muscle and adipose tissue was also altered in mice exposed to SR9009 resulting in increased energy expenditure. In Diet-induced obese mice SR9009 (100 mg/kg i.p. b.i.d. for 30 days) could decrease fat mass and markedly improve dyslipidemia and hyperglycemia. purity: 99%

Catalog No. 50-258-0162