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Medchemexpress LLC SR9011 hydrochloride | 2070014-94-5 | 98.97% | 515.50 | 100 MG
Supplier: Medchemexpress LLC HY16988A100MG
SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. It is for research use only.
- Increases REV-ERB-dependent repressor activity.
- Suppresses proliferation of breast cancer cell lines, regardless of ER or HER2 status.
- Causes cell cycle arrest prior to M phase by suppressing Cyclin A (CCNA2).
- Suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner.
- Displays reasonable plasma exposure in vivo.
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