Medchemexpress LLC SR9011 hydrochloride | 2070014-94-5 | 99.0% | 515.50 | 1 ML

Supplier:  Medchemexpress LLC HY16988A10MM/1ML

SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. This compound offers several key features and benefits:

• Acts as a REV-ERBα/β agonist
• Suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner
• Suppresses proliferation of breast cancer cell lines
• Appears to pause the cell cycle of breast cancer cells prior to M phase
• Causes an increase in cells in the G0/G1 phase and a decrease of cells in S and G2/M phase
• Displays reasonable plasma exposure in vivo
• Suppresses plasminogen activator inhibitor type 1 gene (Serpine1), cholesterol 7α-hydroxylase (Cyp7a1), and sterol response element binding protein (Srepf1) in a dose-dependent manner in mice
• Administration to mice results in loss of locomotor activity during the subject dark phase

Catalog No. 50-003-93510