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Medchemexpress LLC SR9011 hydrochloride | 2070014-94-5 | 99.0% | 515.50 | 2 MG
SDP

Catalog No. 5000393850
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SR9011 hydrochloride is a potent REV-ERBα/β agonist (IC50s: 790 nM for REV-ERBα, 560 nM for REV-ERBβ). It significantly increases REV-ERB-dependent repressor activity and suppresses transcription via full-length REV-ERBα. The compound inhibits BMAL1 mRNA expression in HepG2 cells and suppresses breast cancer cell proliferation by halting the cell cycle before M phase. In mice, SR9011 suppresses REV-ERB responsive genes and temporarily reduces locomotor activity during the dark phase.

  • Potent REV-ERBα/β agonist.
  • Increases REV-ERB-dependent repressor activity.
  • Suppresses transcription via full-length REV-ERBα.
  • Inhibits BMAL1 mRNA expression in HepG2 cells.
  • Suppresses breast cancer cell proliferation.
  • Pauses cell cycle prior to M phase, increasing G0/G1 phase cells.
  • Suppresses REV-ERB responsive genes in mice.
  • Reduces locomotor activity in mice under dark conditions.

Catalog No. 50-003-93850 Supplier Medchemexpress LLC Supplier No. HY16988A2MG
May include imposed supplier surcharges.
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SR9011 hydrochloride is a potent REV-ERBα/β agonist (IC50s: 790 nM for REV-ERBα, 560 nM for REV-ERBβ). It significantly increases REV-ERB-dependent repressor activity and suppresses transcription via full-length REV-ERBα. The compound inhibits BMAL1 mRNA expression in HepG2 cells and suppresses breast cancer cell proliferation by halting the cell cycle before M phase. In mice, SR9011 suppresses REV-ERB responsive genes and temporarily reduces locomotor activity during the dark phase.

  • Potent REV-ERBα/β agonist.
  • Increases REV-ERB-dependent repressor activity.
  • Suppresses transcription via full-length REV-ERBα.
  • Inhibits BMAL1 mRNA expression in HepG2 cells.
  • Suppresses breast cancer cell proliferation.
  • Pauses cell cycle prior to M phase, increasing G0/G1 phase cells.
  • Suppresses REV-ERB responsive genes in mice.
  • Reduces locomotor activity in mice under dark conditions.

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