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Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 25 MG
Supplier: Medchemexpress LLC 25MGHY141623
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. This compound can be used for type 2 diabetes research.
- Inhibits activity of human TXNIP promoter in INS-1 cells.
- Decreases mRNA and protein levels of TXNIP in INS-1 cells.
- Inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter.
- Lowers glucagon secretion in TC1-6 cells.
- Inhibits glucagon-induced glucose output from primary hepatocytes.
- Decreases glucagon secretion and action in mice.
- Blocks hepatic glucose output in mice.
- Reverses obesity- and streptozotocin-induced diabetes and hepatic steatosis in mice.
- Well tolerated in male C57BL/6J mice.
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