Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Sri-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 250 MG
Supplier: Medchemexpress LLC 250MGHY141623
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. It can be used for type 2 diabetes research.
- Inhibits activity of human TXNIP promoter in INS-1 cells.
- Inhibits mRNA and protein levels of TXNIP.
- Inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter.
- Lowers glucagon secretion in TC1-6 cells.
- Inhibits glucagon-induced glucose output from primary hepatocytes.
- Decreases glucagon secretion and blocks hepatic glucose output in mice.
- Reverses obesity- and STZ-induced diabetes and hepatic steatosis in mice.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?